In vitro physicochemical and biological properties of titanium alloy, zirconia, polyetheretherketone, and carbon fiber-reinforced polyetheretherketone

Implant repair is a common means to restore the normal function of hard tissues (bone or teeth). At present, commonly and potentially used implant materials include titanium alloy (Ti), zirconia (Zr), polyetheretherketone (PEEK), 30% carbon fiber reinforced PEEK (CFR-PEEK). This study compares their physicochemical biological properties, including surface morphology, contact angle, nano hardness, elastic modulus, impact on proliferation osteogenic differentiation bone marrow mesenchyml stem cell. Additionally, differences in bacteria adhesion rates among were compared. CFR-PEEK had highest followed by PEEK, Zr, Ti. Zr hardness modulus elasticity, Ti, CRF-PEEK, PEEK. There was no statistically significant difference cytotoxicity based liquid extract test. However, relative cell rate slightly lower than that Ti Zr. Moreover, alkaline phosphatase activity, extracellular matrix mineralization, gene expression with higher at Day 7, showed level 14. greatest number bacterial colonies adhered it, CFR-PEEK, While mechanical properties closer tissue anti-adhesion effect against better those modification methods are needed improve these biopolymers.